The InSight lander is being targeted at a flat plain just north of the planet's equator called Elysium Planitia.
It carries a suite of instruments - many of them from Europe - to try to determine the rocky world's internal structure.
Signals from the probe confirming its safe touchdown should be received at 19:53 GMT, give or take a minute.
As with previous surface missions, InSight must survive the "seven minutes of terror" - the time it takes for a probe entering Mars' thin atmosphere at hypersonic speed to slow to walking pace and gently put itself on the ground.
Many have tried; most have failed. "As humanity, as explorers - we're batting at less than 50%," said Nasa's science chief, Thomas Zurbuchen. "Going to Mars is really, really hard."
Nasa's Mars InSight mission heads for '7 minutes of terror'
The American space agency Nasa will attempt to put another robotic probe on Mars later.
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